Just say not to drugs kids! Err ... unless the dentist gives you drugs from one of the most dangerous and addictive classes of drugs in existence. Then you can pop 'em like candy!

Raeford Brown, anesthesiologist and pediatrician at the University of Kentucky, says “We’ve known for some time that there’s a relationship between the exposure to opioids ... and people becoming addicted to opioids". No shit Sherlock! ;-P

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"We should remember that opioids play an important role in helping patients manage acute and chronic pain alike", not to mention the important role they play in the massive profits earned every year by the pharmaceutical corporations that pump out this addictive, lethal demon-jizz. Oh and here's the punchline ...

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"But while we wait for researchers to successfully develop non-addictive painkillers ..." people who make comments like this in articles on sites with the word "science" in the name should be pelted with rotten fruit for not mentioning the obvious solution; medical cannabis. Now legal in over 30 US states. Excellent for pain relief. Well known to be non-addictive, and certainly much less habit-forming or toxic than opioids or alcohol.

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@strypey You might want to read Bruce Alexander's works on addiction, he studies it through the lens of psychology instead of focusing on chemistry, with quite interesting results.


@jkb I'm aware of the psychological theories that self-sabotaging habits can be caused by an obsessive-compulsive condition, rather than being caused by the thing people are addicted to. This is clearly the case with non-chemical "addictions" to gambling, sex, the net, and so on. I would argue we need a word to describe these, and a different word to describe chemical dependence.

@jkb ... because it's well-established that some chemicals are physically addictive, to the point that there is physical as well as psychological suffering when they're withdrawn. It's equally clear from that research that opioids are among the most addictive substances, and that cannabis use does *not* create chemical dependence in this way, although like gambling or sex, it can be the focus of self-sabotaging habits.

@jkb I'm not talking about behaviour experiments on rats either, I don't consider such vivisection to be scientific at all, let alone produce results that can be applied to humans. I'm talking about decades of clinical observations and social science research on the experiences of people using different drugs, and trying to stop using them.

@strypey Here's a non-rodent result then: "Having found that rather low readdiction rates apply to men who had really been addicted in Vietnam and who had been back in the United States long enough to become readdicted if the wished to or were driven to it by unbearable craving, we need to rethink public policy with respect to forced treatment." Robins, David, and Nurco in the American Journal of Public Health, 1974.


@jkb thanks, I'll have a skim. That link didn't work for me, but here's the for that article:

> "At this point, we do not know whether their high remission rate at 8 to 12 months after return will be long lasting. To learn this, we are planning to reinterview these veterans after they have been home three years."

Was this done? Where is the article on this follow-up study?

@strypey Here's all I found online on that follow-up study: doi.org/10.1111/j.1521-0391.20

"In 1974, we selected 617 men for reintervew. These men were interviewed between October and December of 1974, 3 years after their return from Vietnam […]."

@strypey Also interesting is the work of Zinberg & al. on addiction (or rather, non-addiction) after opiates usage in a medical environment, but I'm afraid I don't have time to fight paywalls to get you the actual papers right now.

@jkb OK, but it seems to me that these are all edge cases. If it remains true that there are substances that when taken for more than a certain length of time, most people experience chemical dependence, and have to go through a physically unpleasant process of withdrawal when they stop. Caffeine, nicotine, and alcohol are all this category, and opioids have one of the shortest windows for establishing dependence, and most unpleasant withdrawal symptoms. Unless you have evidence this is wrong?

@jkb Anyone who has seen someone try to give up an opioid substance, or seen a friend convince themselves they have a flu so they can go get some codeine, knows how addictive opioids are. Anyone who has known long-term junkies know how hard regular opioid use is on the body, and the mind.

@strypey I'm not jumping to conclusions in either direction.Let's stay on topic: your original toot was about prescription opioids in the context of dental surgery, which to me seems like it falls in the same category as morphine usage after other surgeries, we're not talking about long-term daily users here; and we're certainly not talking about people who being beaten down by life turn to downer drugs and become junkies.

Trouble is: research on addiction is scarce and unsufficiently funded.

@strypey Full disclosure: I'm a cannabis user myself, have been for 20 years now, and smoke weed on a daily basis. When I go on vacation where it could get me into legal trouble I don't bring any and indeed I don't feel any withdrawal symptom at all. Clearly that's not addiction.

On the other hand I have a couple friends who can't sleep at all and can't focus on anything if they go a day without weed. Is that addiction? I don't know for sure, but it looks like addiction to me.

@jkb what you describe would also be the experience of many people if you took the internet away for a day. It doesn't even begin to compare to the physical symptoms of caffeine withdrawal, let alone opium withdrawal.

@strypey You're right, it's addiction but on a different level and scale, and that's what I meant by saying we have to do more research on the whole subject of addiction: it's not only psychological, it's not only physical, it's not well-understood enough and yet we play with potentially addictive drugs everywhere all the time (be it medical, recreative, or otherwise).

@jkb I think it's pretty clear that *anything* can be psychologically habit-forming, and that some substances are highly addictive (eg opioids, nicotine, alcohol, tranquilizers, most amphetamines), some are moderately addictive (eg caffein), some are not addictive (eg cannabis, MDMA), and some are anti-addictive (eg entheogens like LSD, psilocybin, mescaline)


@jkb I know the plural of anecdote is not data and all that. But this is the very consistent pattern that's emerged from my observations of my own drug use, and all the people I've seen use a lot of different drugs over a lot of years (I'm over 40 now), plus the stories I've heard from people about their observations. Also from the reading I've done as a drug law reform activist, including Nutt et al:

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